Gene Variant Detail

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Gene BRAF
Variant I463W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF I463W lies within the protein kinase domain of the Braf protein (UniProt.org). I463W has been demonstrated to confer resistance to some Braf inhibitors in culture (PMID: 31925410), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Oct 2022).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF I463X BRAF I463W

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Transcript NM_004333.5
gDNA chr7:g.140781619_140781621delATTinsTGG
cDNA c.1387_1389delATTinsTGG
Protein p.I463W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References