Gene Variant Detail

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Gene BRAF
Variant I463W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF I463W lies within the protein kinase domain of the Braf protein (UniProt.org). I463W has been demonstrated to confer resistance to some Braf inhibitors in culture (PMID: 31925410), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF I463X BRAF I463W

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Transcript NM_004333.6
gDNA chr7:g.140781619_140781621delATTinsTGG
cDNA c.1387_1389delATTinsTGG
Protein p.I463W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781619_140781621delATTinsTGG c.1387_1389delATTinsTGG p.I463W RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140776953_140776955delATCinsTGG c.1387_1389delATCinsTGG p.I463W RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References