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Gene FGFR1
Variant V561F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 V561F lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). V561F has been associated with resistance to FGFR inhibitors in culture (PMID: 34114373), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Mar 2023).
Associated Drug Resistance Y
Category Variants Paths

FGFR1 mutant FGFR1 V561F

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Transcript NM_023110.2
gDNA chr8:g.38416041_38416043delGTGinsTTT
cDNA c.1681_1683delGTGinsTTT
Protein p.V561F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716303.3 chr8:g.38416041_38416043delGTGinsTTT c.1681_1683delGTGinsTTT p.V561F RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38416041_38416043delGTGinsTTT c.1681_1683delGTGinsTTT p.V561F RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38416041_38416043delGTGinsTTT c.1681_1683delGTGinsTTT p.V561F RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38416041_38416043delGTGinsTTT c.1681_1683delGTGinsTTT p.V561F RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 V561F Advanced Solid Tumor predicted - resistant Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 V561F demonstrated insensitivity to Balversa (erdafitinib) in culture (PMID: 34114373). 34114373
FGFR1 V561F Advanced Solid Tumor sensitive HQP1351 Preclinical - Cell line xenograft Actionable In a preclinical study, GZD824 (HQP1351) treatment inhibited cell growth, Fgfr1 phosphorylation, and downstream pathway activation and induced cell cycle arrest and apoptosis in cells expressing FGFR1 V561F in culture and inhibited tumor growth in cell line xenograft models, with a tumor growth inhibition of 73.4% (PMID: 34114373). 34114373
FGFR1 V561F Advanced Solid Tumor resistant Infigratinib Preclinical - Cell line xenograft Actionable In a preclinical study, Truseltiq (infigratinib) treatment failed to inhibit cell growth, Fgfr1 phosphorylation, and downstream pathway activation in cells expressing FGFR1 V561F in culture and failed to inhibit tumor growth in a cell line xenograft model with a tumor growth inhibition of 2.4% (PMID: 34114373). 34114373
FGFR1 V561F Advanced Solid Tumor predicted - resistant Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, treatment with Pemazyre (pemigatinib) failed to inhibit cell growth and Fgfr1 downstream signaling in cells expressing FGFR1 V561F in culture (PMID: 34114373). 34114373
FGFR1 V561F Advanced Solid Tumor predicted - resistant Futibatinib Preclinical - Cell culture Actionable In a preclinical study, treatment with Lytgobi (futibatinib) failed to inhibit cell growth and Fgfr1 downstream signaling in cells expressing FGFR1 V561F in culture (PMID: 34114373). 34114373