Gene Variant Detail

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Gene ALK
Variant Y1096A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK Y1096A lies within the cytoplasmic domain of the Alk protein (UniProt.org). Y1096A is not activating in an in vitro assay and is not transforming in culture (PMID: 33674381), but has not been fully biochemically characterized and therefore, its effect on Alk protein function is unknown.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK Y1096A

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Transcript NM_004304.4
gDNA chr2:g.29223414_29223415delTAinsGC
cDNA c.3286_3287delTAinsGC
Protein p.Y1096A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29223414_29223415delTAinsGC c.3286_3287delTAinsGC p.Y1096A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References