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Gene CDK12
Variant G1461Afs*38
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions CDK12 G1461Afs*38 indicates a shift in the reading frame starting at amino acid 1461 and terminating 38 residues downstream, resulting in premature truncation of the functional protein and extension of the 1490 aa Cdk12 protein length by nine amino acids (UniProt.org). G1461Afs*38 has been identified in the scientific literature (PMID: 35452513), but has not been biochemically characterized and therefore, its effect on Cdk12 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 G1461Afs*38

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Transcript NM_016507.4
gDNA chr17:g.39531225delG
cDNA c.4382delG
Protein p.G1461Afs*38
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_016507.4 chr17:g.39531225delG c.4382delG p.G1461Afs*38 RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39531225delG c.4382delG p.G1461Afs*38 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References