Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Gene | ALK |
Variant | del exon3 |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | ALK del exon3 indicates a deletion of exon 3 of the ALK gene. |
Associated Drug Resistance | |
Category Variants Paths |
ALK mutant ALK del exon3 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK del exon2 ALK del exon3 ALK amp | neuroblastoma | sensitive | Ceritinib + Ribociclib | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of Zykadia (ceritinib) and Kisqali (ribociclib) inhibited proliferation in a neuroblastoma cell line harboring a deletion of ALK exons 2 and 3 and ALK amplification in culture (PMID: 27986745). | 27986745 |