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Gene | PALB2 |
Variant | del exon11 |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | PALB2 del exon11 indicates a deletion of exon 11 of the PALB2 gene. |
Associated Drug Resistance | |
Category Variants Paths |
PALB2 mutant PALB2 del exon11 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PALB2 del exon11 | endometrial serous adenocarcinoma | predicted - sensitive | Olaparib | Case Reports/Case Series | Actionable | In a clinical case study, Lynparza (olaparib) treatment resulted in a durable response lasting 23 months in a patient with recurrent serous endometrial carcinoma harboring a germline deletion of PALB2 exon 11 (PMID: 34781271). | 34781271 |