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Gene | PIK3CA |
Variant | W11C |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | PIK3CA W11C does not lie within any known functional domains of the Pik3ca protein (UniProt.org). W11C has been identified in the scientific literature (PMID: 33754015, PMID: 37713162), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Jan 2024). |
Associated Drug Resistance | |
Category Variants Paths |
PIK3CA mutant PIK3CA W11C |
Transcript | NM_006218.4 |
gDNA | chr3:g.179198858G>T |
cDNA | c.33G>T |
Protein | p.W11C |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_006218.4 | chr3:g.179198858G>T | c.33G>T | p.W11C | RefSeq | GRCh38/hg38 |
XM_006713658.5 | chr3:g.179198858G>T | c.33G>T | p.W11C | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E PIK3CA W11C PIK3CA E542K | thyroid gland papillary carcinoma | sensitive | Dasatinib + Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of Sprycel (dasatinib) and Mekinist (trametinib) inhibited viability of a papillary thyroid cancer cell line harboring BRAF V600E and PIK3CA E542K and W11C in culture (PMID: 37713162). | 37713162 |