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Gene | BRAF |
Variant | G606A |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | BRAF G606A lies within the protein kinase domain of the Braf protein (UniProt.org). G606A has been identified in sequencing studies (PMID: 21825258), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2024). |
Associated Drug Resistance | |
Category Variants Paths |
BRAF mutant BRAF G606A |
Transcript | NM_004333.6 |
gDNA | chr7:g.140753318C>G |
cDNA | c.1817G>C |
Protein | p.G606A |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001378468.1 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
NM_004333 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
NM_004333.5 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
XM_005250045 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
NM_004333.6 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
NM_001378474.1 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
NM_001378471.1 | chr7:g.140749351C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
NM_001354609.2 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
NM_001354609.1 | chr7:g.140753318C>G | c.1817G>C | p.G606A | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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