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|Protein Effect||loss of function|
|Gene Variant Descriptions||FBXW7 inact mut indicates that this variant results in a loss of function of the Fbxw7 protein. However, the specific amino acid change has not been identified.|
|Associated Drug Resistance|
|Category Variants Paths||
FBXW7 mutant FBXW7 inact mut
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FBXW7 mutant||Her2-receptor negative breast cancer||predicted - sensitive||LY3039478||Case Reports/Case Series||Actionable||In a Phase I trial, LY3039478 treatment resulted in partial response lasted 9.5 months in a patient with hormone receptor-positive, Erbb2 (Her2)-negative breast cancer harboring FBXW7 mutation (PMID: 30060061; NCT01695005).||30060061|