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Gene ALK
Variant F1174L
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK F1174L lies within the protein kinase domain of the Alk protein (UniProt.org). F1174L confers a gain of function to the Alk protein as indicated by transformation activity and increased cell proliferation in culture (PMID: 18923525, PMID: 29533785, PMID: 29907598), and has been demonstrated to occur as a secondary resistance mutation in the context of ALK fusions (PMID: 21030459, PMID: 31452835).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK act mut ALK F1174L

ALK mutant ALK F1174X ALK F1174L

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Transcript NM_004304.5
gDNA chr2:g.29220831A>G
cDNA c.3520T>C
Protein p.F1174L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29220831A>G c.3520T>C p.F1174L RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220831A>G c.3520T>C p.F1174L RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29220831A>G c.3520T>C p.F1174L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK F1174L gain of function ALK Inhibitor
ALK F1174L TP53 wild-type
EML4 - ALK ALK F1174L Alectinib AZD3463 Lorlatinib
ALK F1174L AXL pos
ALK F1174L ALK L1198P
ALK G1123S ALK F1174L
ALK G1123D ALK F1174L
EML4 - ALK ALK F1174L ALK L1196M
ALK F1174L ALK amp
EML4 - ALK ALK F1174L ALK L1198V
ALK rearrange ALK F1174L
EML4 - ALK ALK F1174L ALK G1269A
EML4 - ALK ALK F1174L ALK D1203N ALK G1269A
ALK rearrange ALK F1174L ALK G1202R
ALK F1174L ALK pos
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK F1174L ALK G1202R
EML4 - ALK ALK I1171N ALK F1174L
ALK F1174L ALK R1275Q
ALK F1174L RET over exp
EML4 - ALK ALK E1129V ALK I1171T ALK F1174C ALK F1174L ALK F1174V ALK G1269A
EML4 - ALK ALK F1174L ALK S1189C
EML4 - ALK ALK F1174L ALK E1210K ALK G1269A
EML4 - ALK ALK I1171T ALK F1174L ALK L1196M ALK D1203N ALK E1210K ALK G1269A
ALK F1174L NRAS Q61K
ALK F1174L FGFR1 N546K
ALK F1174L PIK3CA H1047R
ALK F1174L ALK G1202R ALK D1203N ALK amp
ALK F1174L ALK L1196M
ALK F1174L ALK G1202R
EML4 - ALK ALK F1174L ALK E1210K