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|Gene Variant Descriptions||KIT positive indicates the presence of the KIT gene, mRNA, and/or protein.|
|Associated Drug Resistance|
|Category Variants Paths|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT positive||germ cell cancer||no benefit||Imatinib||Phase II||Actionable||In a small Phase II study, 6 patients with KIT-positive refractory germ cell tumors treated with Gleevec (imatinib) experienced no significant antitumor activity (PMID: 16462496).||16462496|
|KIT positive||gastrointestinal stromal tumor||sensitive||Imatinib||FDA approved||Actionable||In a Phase II trial that supported FDA approval, treatment with Gleevec (imatinib) resulted in an overall response rate of 38% (56/147) and a median duration of response of 13 weeks in patients with metastatic or unresectable KIT-positive GIST (PMID: 12374669).||12374669 detail...|
|KIT positive||prostate neuroendocrine neoplasm||no benefit||Imatinib||Preclinical||Actionable||In a preclinical study, a prostate neuroendocrine tumor mouse model expressing Kit did not respond to Gleevec (imatinib), a result of impaired signaling of the Kit pathway (PMID: 27980106).||27980106|
|KIT positive||breast cancer||predicted - sensitive||Imatinib + Letrozole||Phase 0||Actionable||In a pilot trial, Gleevec (imatinib mesylate) and Femara (letrozole) combination treatment resulted in clinical partial response in 90% (9/10) and stable disease in 10% (1/10) of the evaluable patients with invasive hormone-sensitive breast cancer, 8 of the 13 enrolled patients had KIT-positive tumors (PMID: 18248884).||18248884|