Gene Variant Detail

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Gene CDK12
Variant G677D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 G677D lies within the proline-rich motif region of the Cdk12 protein (PMID: 22512864). G677D has not been characterized in the scientific literature and therefore, its effect on Cdk12 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 G677D

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Transcript NM_016507.4
gDNA chr17:g.39490655G>A
cDNA c.2030G>A
Protein p.G677D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017024749.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524901 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524905 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524899 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524895 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524906 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436264.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_005257456.5 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_005257456.4 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_011524900 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436283.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_005257456 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524892 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024751 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
NM_016507 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436263.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524896 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524902 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024753 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436291.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436280.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_017024744 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524898 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024752 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436285.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436284.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436253.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_005257458 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524897 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524903 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024745 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524907 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436290.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024747 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024748 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436286.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524893 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024753.2 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_047436292.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
NM_015083 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436281.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024746 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024753.3 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524894 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436262.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
XM_017024749 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_017024750 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38
XM_047436282.1 chr17:g.39490658_39490659delGAinsAC c.2030_2031delGAinsAC p.G677D RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39490655G>A c.2030G>A p.G677D RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References