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Gene NTRK1
Variant G613V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NTRK1 G613V lies within the protein kinase domain of the Ntrk1 protein (UniProt.org). G613V is not transforming in culture, but results in increased phosphorylation of Akt in combination with NTRK1 H604Y in patient samples and has been associated with resistance to NTRK inhibitors in cell culture (PMID: 38531265), but has not been individually biochemically characterized and therefore, its effect on Nrtk1 protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

NTRK1 mutant NTRK1 G613V

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Transcript NM_002529.4
gDNA chr1:g.156879154G>T
cDNA c.1838G>T
Protein p.G613V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002529.3 chr1:g.156879154G>T c.1838G>T p.G613V RefSeq GRCh38/hg38
NM_002529.4 chr1:g.156879154G>T c.1838G>T p.G613V RefSeq GRCh38/hg38
NM_002529 chr1:g.156879154G>T c.1838G>T p.G613V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 G613V dedifferentiated liposarcoma resistant Larotrectinib Preclinical - Cell culture Actionable In a preclinical study, a dedifferentiated liposarcoma cell line expressing NTRK1 G613V demonstrated resistance to Vitrakvi (larotrectinib) in culture (PMID: 38531265). 38531265
NTRK1 G613V dedifferentiated liposarcoma resistant Selitrectinib Preclinical - Cell culture Actionable In a preclinical study, a dedifferentiated liposarcoma cell line expressing NTRK1 G613V demonstrated resistance to Selitrectinib (LOXO-195) in culture (PMID: 38531265). 38531265