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Gene RET
Variant C634R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET C634R lies within the extracellular domain of the Ret protein (UniProt.org). C634R results in autophosphorylation of Ret, and is transforming in cultured cells (PMID: 9242375, PMID: 10679286).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C634R

RET mutant RET C634X RET C634R

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Transcript NM_020975.6
gDNA chr10:g.43114500T>C
cDNA c.1900T>C
Protein p.C634R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_020975 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43123795T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43123795T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_020630 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114500T>C c.1900T>C p.C634R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634R RET V804G Advanced Solid Tumor sensitive Vandetanib Preclinical Actionable In a preclinical study, transformed cell lines expressing Ret protein carrying both C634R and V804G mutations were more sensitive to Vandetanib induced inhibition of Ret activity than cells expressing Ret C634R alone in culture (PMID: 15184865). 15184865
RET C634R RET V804M Advanced Solid Tumor resistant Vandetanib Preclinical - Cell culture Actionable In a preclinical study, transformed human cells co-expressing RET C634R and RET V804M were resistant to treatment with Caprelsa (vandetanib) in culture (PMID: 19029224). 19029224
RET C634R RET Y806C Advanced Solid Tumor resistant Vandetanib Preclinical - Cell culture Actionable In a preclinical study, transformed human cells co-expressing RET C634R and RET Y806C were resistant to treatment with Caprelsa (vandetanib) in culture (PMID: 19029224). 19029224
RET C634R RET Y806E Advanced Solid Tumor resistant Vandetanib Preclinical - Cell culture Actionable In a preclinical study, transformed human cells co-expressing RET C634R and RET Y806E were resistant to treatment with Caprelsa (vandetanib) in culture (PMID: 19029224). 19029224
RET C634R RET Y806F Advanced Solid Tumor predicted - sensitive Vandetanib Preclinical - Cell culture Actionable In a preclinical study, transformed human cells co-expressing RET C634R and RET Y806F in culture demonstrated inhibition of Ret phosphorylation and activity in kinase assays when treated with Caprelsa (vandetanib) (PMID: 19029224). 19029224