Gene Variant Detail

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Gene ARID1A
Variant P20_P21dup
Impact List duplication
Protein Effect loss of function
Gene Variant Descriptions ARID1A P20_P21dup (also reported as P16_P17dup) indicates the insertion of 2 duplicate amino acids, proline (P)-20 through proline (P)-21, in the Arid1a protein (UniProt.org). P20_P21dup (reported as P16_P17dup) leads to a loss of Arid1a function as indicated by reduced Cdkn1a expression and uninhibited cell growth in culture (PMID: 23097632).
Associated Drug Resistance
Category Variants Paths

ARID1A mutant ARID1A inact mut ARID1A P20_P21dup

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Transcript NM_006015.6
gDNA chr1:g.26696461_26696466
cDNA c.58_63
Protein p.P20_P21
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_139135 chr1:g.26696461_26696466 c.58_63 p.P20_P21 RefSeq GRCh38/hg38
NM_006015.6 chr1:g.26696461_26696466 c.58_63 p.P20_P21 RefSeq GRCh38/hg38
NM_139135.3 chr1:g.26696461_26696466 c.58_63 p.P20_P21 RefSeq GRCh38/hg38
NM_006015 chr1:g.26696460_26696465dupGCCGCC c.57_62dupGCCGCC p.P20_P21dup RefSeq hg38
NM_006015 chr1:g.26696461_26696466 c.58_63 p.P20_P21 RefSeq GRCh38/hg38
NM_006015.5 chr1:g.26696461_26696466 c.58_63 p.P20_P21 RefSeq GRCh38/hg38
NM_139135.4 chr1:g.26696461_26696466 c.58_63 p.P20_P21 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
ARID1A P20_P21dup loss of function EZH2 inhibitor