Molecular Profile Detail

Profile Name BRAF V600D PTEN loss
Gene Variant Detail

BRAF V600D (gain of function)

PTEN loss (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600D PTEN loss melanoma sensitive XL147 Preclinical - Cell line xenograft Actionable In a preclinical study, XL147 inhibited tumor growth in xenograft models of a PTEN-deficient human melanoma cell line harboring BRAF V600D (PMID: 25637314). 25637314
Clinical Trial Phase Therapies Title Recruitment Status