Molecular Profile Detail


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Profile Name CBL dec exp
Gene Variant Detail

CBL dec exp (no effect)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
CBL dec exp pancreatic ductal carcinoma predicted - sensitive Erlotinib + Gemcitabine Preclinical - Cell line xenograft Emerging In a preclinical study, addition of Tarceva (erlotinib) overcame Gemzar (gemcitabine)-resistance in pancreatic ductal carcinoma cell lines with reduced Cbl expression via shRNA, resulted in decreased viability in cell culture and reduced tumor growth in cell line xenograft models (PMID: 25348515). 25348515
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries