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|Profile Name||CBL dec exp|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|CBL dec exp||pancreatic ductal carcinoma||predicted - sensitive||Erlotinib + Gemcitabine||Preclinical - Cell line xenograft||Emerging||In a preclinical study, addition of Tarceva (erlotinib) overcame Gemzar (gemcitabine)-resistance in pancreatic ductal carcinoma cell lines with reduced Cbl expression via shRNA, resulted in decreased viability in cell culture and reduced tumor growth in cell line xenograft models (PMID: 25348515).||25348515|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|