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Profile Name | MST1R pos PIK3CA E545K |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
MST1R pos PIK3CA E545K | breast cancer | predicted - sensitive | Buparlisib | Preclinical - Cell culture | Actionable | In a preclinical study, BKM120 decreased viability of a breast cancer cell line expressing the constitutively active short isoform of MST1R (RON) and PIK3CA E545K in culture (PMID: 26289070). | 26289070 | |
MST1R pos PIK3CA E545K | breast cancer | predicted - sensitive | BMS-777607 | Preclinical - Cell culture | Actionable | In a preclinical study, BMS-777607 decreased viability of a breast cancer cell line expressing the constitutively active short isoform of MST1R (RON) and PIK3CA E545K in culture (PMID: 26289070). | 26289070 |