Molecular Profile Detail


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Profile Name PIK3CA R88L PIK3CA E453del PIK3CA T1052K PTEN loss PTEN mut
Gene Variant Detail

PIK3CA E453del (unknown)

PIK3CA R88L (unknown)

PIK3CA T1052K (unknown)

PTEN loss (loss of function)

PTEN mutant (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA R88L PIK3CA E453del PIK3CA T1052K PTEN loss PTEN mut endometrial carcinoma sensitive Copanlisib Phase I Actionable In a Phase I clinical trial, an endometrial carcinoma patient harboring PIK3CA T1052K, R88L, and E453del, as well as a PTEN mutation and loss of PTEN protein expression demonstrated a complete response to treatment with Aliqopa (copanlisib) (PMID: 27672108). 27672108