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|Profile Name||ATM over exp|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ATM over exp||stomach cancer||decreased response||Veliparib||Preclinical - Cell culture||Actionable||In a preclinical study, high ATM expression was associated with decreased response to Veliparib (ABT-888) in gastric cancer cell lines in culture (PMID: 27638859).||27638859|
|ATM over exp||stomach cancer||sensitive||Irinotecan + Veliparib||Preclinical - Cell line xenograft||Actionable||In a preclinical study, the combination of Camptosar (irinotecan) and Veliparib (ABT-888) demonstrated synergy in gastric cancer cell lines with high ATM expression, resulting in increased apoptosis in culture, and enhanced tumor growth inhibition in cell line xenograft models (PMID: 27638859).||27638859|
|ATM over exp||stomach cancer||decreased response||Irinotecan||Preclinical - Cell culture||Actionable||In a preclinical study, high ATM expression was associated with decreased response to Camptosaur (irinotecan) in gastric cancer cell lines in culture (PMID: 27638859).||27638859|