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|Profile Name||ALK rearrange ALK D1203N ALK E1210K ALK G1269A|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ALK rearrange ALK D1203N ALK E1210K ALK G1269A||lung non-small cell carcinoma||resistant||Lorlatinib||Case Reports/Case Series||Actionable||In a clinical study, ALK G1269A was identified as an acquired mutation in an ALK-positive non-small cell lung cancer patient harboring ALK E1210K and D1203N, who developed resistance to Lorlatinib (PF-06463922) after initial response (PMID: 29650534).||29650534|