Molecular Profile Detail


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Profile Name IDH1 R132C IDH1 S280F
Gene Variant Detail

IDH1 R132C (gain of function)

IDH1 S280F (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132C IDH1 S280F acute myeloid leukemia predicted - resistant Ivosidenib Case Reports/Case Series Actionable In a clinical study, IDH1 S280F was identified as an acquired mutation in cis with the original IDH1 R132C in a patient with acute myeloid leukemia (AML), who developed resistance to Tibsovo (ivosidenib) after initial response (PMID: 29950729). 29950729
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries