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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|IDH1 R132C IDH1 S280F||acute myeloid leukemia||predicted - resistant||Ivosidenib||Case Reports/Case Series||Actionable||In a clinical study, IDH1 S280F was identified as an acquired mutation in cis with the original IDH1 R132C in a patient with acute myeloid leukemia (AML), who developed resistance to Tibsovo (ivosidenib) after initial response (PMID: 29950729).||29950729|
|IDH1 R132C IDH1 S280F||acute myeloid leukemia||predicted - resistant||Ivosidenib||Case Reports/Case Series||Actionable||In a clinical case study, a patient with acute myeloid leukemia (AML) harboring IDH1 R132C progressed following an initial response to treatment with Tibsovo (ivosidenib), and was found to have acquired IDH1 S280F (PMID: 33832922).||33832922|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|