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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ALK rearrange ALK D1203N||lung non-small cell carcinoma||predicted - resistant||Brigatinib||Case Reports/Case Series||Actionable||In a clinical case study, ALK D1203N was identified at disease progression while on Alunbrig (brigatinib) treatment in a patient with ALK-positive non-small cell lung cancer (PMID: 29935304).||29935304|
|ALK rearrange ALK D1203N||lung non-small cell carcinoma||predicted - resistant||Lorlatinib||Clinical Study - Cohort||Actionable||In a retrospective study, ALK D1203N was identified in 24% (7/29) of plasma samples at disease progression in ALK-positive non-small cell lung cancer patients who received Lorbrena (lorlatinib) treatment (PMID: 31358542).||31358542|