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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA E545V||ovarian clear cell adenocarcinoma||sensitive||mTOR Inhibitor PI3K Inhibitor (Pan)||DS-7423||Preclinical - Cell culture||Actionable||In a preclinical study, an ovarian clear cell adenocarcinoma cell line harboring PIK3CA E545V was sensitive to DS-7423 in culture, demonstrating inhibition of cell proliferation (PMID: 24504419).||24504419|