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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA M1043I||endometrial adenocarcinoma||no benefit||PIK3CA inhibitor||Copanlisib||Case Reports/Case Series||Actionable||In a Phase II (NRG-GY008) trial, Aliqopa (copanlisib) was well tolerated but demonstrated limited efficacy, resulted in stable disease in a patient with endometrioid adenocarcinoma harboring PIK3CA M1043I (PMID: 31934607).||31934607|
|PIK3CA M1043I||lung squamous cell carcinoma||no benefit||PIK3CA inhibitor||Taselisib||Case Reports/Case Series||Actionable||In a Phase I (SWOG S1400B) trial, Taselisib (GDC-0032) treatment did not meet its primary endpoint for response rate in patients with lung squamous cell carcinoma harboring PIK3CA mutations, resulting in no response in a patient harboring PIK3CA M1043I (PMID: 31158500; NCT02785913).||31158500|