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|Profile Name||PIK3CA E542K PIK3CA F744L|
|Gene Variant Detail||
PIK3CA E542K (gain of function)
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA E542K PIK3CA F744L||head and neck squamous cell carcinoma||sensitive||Sulindac||Preclinical - Pdx||Actionable||In a preclinical study, Clinoril (sulindac) treatment reduced tumor growth rate in patient-derived xenograft (PDX) models of head and neck squamous cell carcinoma harboring PIK3CA mutations, including a model harboring PIK3CA E542K and PIK3CA F744L (PMID: 30683736).||30683736|