Molecular Profile Detail

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Profile Name FGFR2 K660N FGFR2 amp
Gene Variant Detail

FGFR2 amp (no effect)

FGFR2 K660N (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 K660N FGFR2 amp stomach cancer predicted - resistant AZD4547 Preclinical - Cell culture Actionable In a preclinical study, a gastric cancer cell line harboring an FGFR2 amplification was found to have developed resistance to AZD4547 after prolonged exposure in culture, and was subsequently found to have acquired FGFR2 K660N (PMID: 32973082). 32973082