Molecular Profile Detail


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Profile Name ATM R1882* ATM R3008H
Gene Variant Detail

ATM R1882* (loss of function - predicted)

ATM R3008H (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM R1882* ATM R3008H pancreatic cancer predicted - sensitive Berzosertib + Irinotecan Case Reports/Case Series Actionable In a Phase I trial, the combination of Berzosertib (VX-970) and Camptosar (irinotecan) was tolerated in patients with advanced solid tumors, and resulted in a partial response that was ongoing at 11 months in a pancreatic cancer patient harboring ATM R3008H and germline ATM R1882* (J Clin Oncol 40, 2022 (suppl 16; abstr 3012); NCT02595931). detail...