Molecular Profile Detail


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Profile Name FLT3 amp
Gene Variant Detail

FLT3 amp (no effect)

Relevant Treatment Approaches FLT3 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 amp colorectal cancer predicted - sensitive FLT3 Inhibitor Sorafenib Case Reports/Case Series Actionable In a clinical case study, Nexavar (sorafenib) treatment targeting FLT3 amplification in a rectal adenocarcinoma patient who had progressed on all standard therapies resulted in rapid clinical improvement (PMID: 25848357). 25848357
FLT3 amp colorectal cancer no benefit FLT3 Inhibitor Sunitinib Phase II Actionable In a Phase II trial (TAPUR), treatment with Sutent (sunitinib) did not demonstrate clinical activity in patients with colorectal cancer with FLT3 amplification (n=10), resulting in no objective responses and stable disease at 16 weeks in 2 patients (PMID: 33068284; NCT02693535). 33068284