Molecular Profile Detail


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Profile Name FLT3 over exp
Gene Variant Detail

FLT3 over exp (no effect)

Relevant Treatment Approaches FLT3 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 over exp hepatocellular carcinoma sensitive FLT3 Inhibitor Sorafenib Clinical Study Actionable In an observational clinical study, hepatocellular carcinoma patients harboring FLT3 overexpression treated with Nexavar (sorafenib) demonstrated improved overall survival (24.9 months (n=67)) when compared to patients with FLT3 overexpression who received a control treatment (10.0 months (n=49)) or patients with decreased FLT3 expression treated with Nexavar (sorafenib) (16.0 months (n=71)) (PMID: 32332018). 32332018
FLT3 over exp hepatocellular carcinoma sensitive FLT3 Inhibitor Sorafenib Preclinical - Pdx Actionable In a preclinical study, Nexavar (sorafenib) inhibited tumor growth and reduced the percentage of tumor cells expressing Ki-67 in patient-derived xenograft (PDX) models of hepatocellular carcinoma harboring FLT3 overexpression, but had no effect on tumor growth inhibition or Ki-67 expression compared to control treatments in PDX models of HCC harboring decreased FLT3 expression (PMID: 32332018). 32332018