Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Profile Name | ERBB3 D297H |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
ERBB3 D297H | head and neck squamous cell carcinoma | sensitive | Neratinib | Preclinical - Cell culture | Actionable | In a preclinical study, Nerlynx (neratinib) treatment inhibited viability of a hypopharyngeal squamous cell carcinoma cell line harboring ERBB3 (HER3) D297H in culture (PMID: 33473169). | 33473169 | |
ERBB3 D297H | head and neck squamous cell carcinoma | sensitive | Lapatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Tykerb (lapatinib) treatment inhibited viability of a hypopharyngeal squamous cell carcinoma cell line harboring ERBB3 (HER3) D297H in culture (PMID: 33473169). | 33473169 |