Molecular Profile Detail

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Profile Name PIK3CA amp PTEN H123P
Gene Variant Detail

PIK3CA amp (no effect)

PTEN H123P (loss of function - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA amp PTEN H123P triple-receptor negative breast cancer predicted - sensitive Alpelisib + Everolimus Preclinical - Pdx & cell culture Actionable In a preclinical study, combination treatment with Piqray (albelisib) and Afinitor (everolimus) synergistically inhibited cell viability of patient-derived triple-negative breast cancer cells harboring PIK3CA amplification and PTEN H123P in culture, and led to inhibition of tumor growth in a patient-derived xenograft (PDX) model (PMID: 36900375). 36900375
PIK3CA amp PTEN H123P triple-receptor negative breast cancer predicted - sensitive Afatinib + Alpelisib Preclinical - Pdx & cell culture Actionable In a preclinical study, combination treatment with Piqray (albelisib) and Gilotrif (afatinib) synergistically inhibited cell viability of patient-derived triple-negative breast cancer cells harboring PIK3CA amplification and PTEN H123P in culture, and led to inhibition of tumor growth in a patient-derived xenograft (PDX) model (PMID: 36900375). 36900375