Molecular Profile Detail


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Profile Name ATM V2288fs
Gene Variant Detail

ATM V2288fs (loss of function - predicted)

Relevant Treatment Approaches Olaparib


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM V2288fs prostate cancer predicted - sensitive Olaparib Olaparib Case Reports/Case Series Actionable In a Phase II trial (TOPARP-A), Lynparza (olaparib) treatment resulted in a conversion in the circulating tumor-cell count, a 29% decrease in PSA level, and radiologic stable disease in a patient with metastatic castration-resistant prostate cancer harboring ATM V2288fs (PMID: 26510020; NCT01682772). 26510020