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Profile Name | BRAF V600E ERBB3 pos |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
BRAF V600E ERBB3 pos | colon cancer | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a cell line xenograft model of ERBB3 (HER3)-positive colon cancer harboring BRAF V600E (PMID: 37302522): | 37302522 | |
BRAF V600E ERBB3 pos | colon cancer | sensitive | AMT-562 + LY2603618 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Rabusertiv (LY2603618) and AMT-562 synergistically inhibited tumor growth in a cell line xenograft model of ERBB3 (HER3)-positive colon cancer harboring BRAF V600E (PMID: 37302522). | 37302522 |