Molecular Profile Detail


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Profile Name FGFR3 Y373C FGFR3 N540K FGFR3 V555L FGFR3 L608V
Gene Variant Detail

FGFR3 L608V (unknown)

FGFR3 N540K (gain of function)

FGFR3 V555L (unknown)

FGFR3 Y373C (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 Y373C FGFR3 N540K FGFR3 V555L FGFR3 L608V bladder urothelial carcinoma predicted - resistant Futibatinib Case Reports/Case Series Actionable In a clinical case study, FGFR3 N540K, FGFR3 V555L, and FGFR3 L608V were identified in the post-progression circulating tumor DNA of a patient with bladder urothelial carcinoma harboring FGFR3 Y373C who previously responded to Lytgobi (futibatinib) treatment (PMID: 37377403). 37377403