Molecular Profile Detail

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Profile Name ATM D2725G
Gene Variant Detail

ATM D2725G (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM D2725G lung small cell carcinoma predicted - sensitive Temozolomide + Veliparib Case Reports/Case Series Actionable In a Phase II trial, Temodar (temozolomide) and Veliparib (ABT-888) combination treatment resulted in partial response in a patient with small cell lung cancer harboring ATM D2725G, with a progression-free survival of 9 months and an overall survival of 16 months (PMID: 29906251; NCT01638546). 29906251