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|Profile Name||ATM V410A|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ATM V410A||lung small cell carcinoma||predicted - sensitive||Temozolomide + Veliparib||Case Reports/Case Series||Actionable||In a Phase II trial, Temodar (temozolomide) and Veliparib (ABT-888) combination treatment resulted stable disease in a patient with small cell lung cancer harboring ATM V410A, with a progression-free survival of 6.3 months and an overall survival of 6.3 months (PMID: 29906251; NCT01638546).||29906251|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|