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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF mutant||Advanced Solid Tumor||predicted - sensitive||KO-947||Preclinical - Pdx||Actionable||In a preclinical study, KO-947 resulted in tumor regression in patient derived xenograft (PDX) models harboring either a BRAF mutation, NRAS mutation, or KRAS mutation (EJC Dec 2016, 69:1; S126).||detail...|
|PubMed Id||Reference Title||Details|
|KO-947, a potent and selective ERK inhibitor with slow dissociation kinetics||Full reference...|