Profile Response Detail

Molecular Profile TP53 wild-type
Therapy ALRN-6924
Indication/Tumor Type Merkel cell carcinoma
Response Type sensitive
Create By cstatz
Update By cstatz


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type Merkel cell carcinoma sensitive ALRN-6924 Phase I Actionable In a Phase I trial, ALRN-6924 treatment in a patient with Merkel cell carcinoma resulted in a complete response (J Clin Oncol 35, 2017 (suppl; abstr 2505)). detail...
PubMed Id Reference Title Details
Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX- and MDM2-mediated inhibition of WT p53 in patients with solid tumors and lymphomas Full reference...