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Molecular Profile | KIT N822I |
Therapy | Imatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT N822I | Advanced Solid Tumor | resistant | Imatinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing KIT N822I demonstrated resistance to Gleevec (imatinib) in culture (PMID: 21689725). | 21689725 |
PubMed Id | Reference Title | Details |
---|---|---|
(21689725) | Novel, activating KIT-N822I mutation in familial cutaneous mastocytosis. | Full reference... |