Profile Response Detail


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Molecular Profile KIT D816Y
Therapy Avapritinib
Indication/Tumor Type mast cell neoplasm
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT D816Y mast cell neoplasm predicted - sensitive Avapritinib Preclinical Actionable In a preclinical study, Ayvakit (avapritinib) inhibited Kit phosphorylation and proliferation of murine mastocytoma cells harboring KIT D814Y (corresponding to human D816Y) in culture, and resulted in tumor regression in allograft animal models (PMID: 29093181). 29093181
PubMed Id Reference Title Details
(29093181) A precision therapy against cancers driven by KIT/PDGFRA mutations. Full reference...