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Molecular Profile | FANCA S1088F |
Therapy | Cisplatin |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FANCA S1088F | Advanced Solid Tumor | sensitive | Cisplatin | Preclinical - Cell culture | Actionable | In a preclinical study, overexpression of FANCA S1088F in FANCA-null cells derived from Fanconi anemia patients resulted in increased sensitivity to Platinol (cisplatin) compared to wild-type Fanca expression in culture (PMID: 28864460). | 28864460 |
PubMed Id | Reference Title | Details |
---|---|---|
(28864460) | A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents. | Full reference... |