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|Molecular Profile||ATM dec exp|
|Indication/Tumor Type||breast cancer|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ATM dec exp||breast cancer||sensitive||Talazoparib||Preclinical - Cell culture||Actionable||In a preclinical study, knockdown of ATM expression sensitized breast cancer cells to treatment with Talzenna (talazoparib) in culture (PMID: 23881923).||23881923|
|PubMed Id||Reference Title||Details|
|(23881923)||BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.||Full reference...|