Molecular Profile Detail

Profile Name ATM dec exp
Gene Variant Detail

ATM dec exp (no effect)

Relevant Treatment Approaches PARP Inhibitor (Pan)

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM dec exp breast cancer sensitive PARP Inhibitor (Pan) Talazoparib Preclinical - Cell culture Actionable In a preclinical study, knockdown of ATM expression sensitized breast cancer cells to treatment with Talzenna (talazoparib) in culture (PMID: 23881923). 23881923
ATM dec exp stomach cancer predicted - sensitive PARP Inhibitor (Pan) Olaparib + Paclitaxel Phase II Actionable In a Phase II trial, addition of Lynparza (olaparib) to Taxol (paclitaxel) did not significantly improve progression free survival (5.29 vs 3.68 months) compared to Taxol alone, but did significantly prolong overall survival (HR = 0.35) in metastatic gastric cancer patients with decreased Atm expression (PMID: 26282658; NCT01063517). 26282658
ATM dec exp stomach cancer sensitive PARP Inhibitor (Pan) Veliparib Preclinical - Cell line xenograft Actionable In a preclinical study, knockdown of ATM in a gastric cancer cell line resulted in increased sensitivity to Veliparib (ABT-888) in culture and in xenograft models (PMID: 27638859). 27638859
Clinical Trial Phase Therapies Title Recruitment Status
NCT02264678 Phase Ib/II AZD6738 AZD6738 + Carboplatin AZD6738 + Durvalumab AZD6738 + Olaparib Ascending Doses of AZD6738 in Combination With Chemotherapy and/or Novel Anti Cancer Agents Recruiting