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|Molecular Profile||PIK3CA H1047R|
|Indication/Tumor Type||head and neck squamous cell carcinoma|
|Response Type||predicted - sensitive|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA H1047R||head and neck squamous cell carcinoma||predicted - sensitive||SHR-A1307||Preclinical - Cell culture||Actionable||In a preclinical study, head and neck squamous cell carcinoma cells harboring PIK3CA H1047R treated with SHR-A1307 demonstrated inhibition of cell growth in culture (PMID: 30962319).||30962319|
|PubMed Id||Reference Title||Details|
|(30962319)||Discovery of A Novel EGFR-Targeting Antibody-Drug Conjugate, SHR-A1307, for the Treatment of Solid Tumors Resistant or Refractory to Anti-EGFR Therapies.||Full reference...|