Therapy Detail

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Therapy Name SHR-A1307
Synonyms
Therapy Description

SHR-A1307 is an antibody-drug conjugate that consists of an auristatin analog linked to the anti-EGFR antibody Nimotuzumab with improved half-life, which inhibits cell growth in culture and reduces tumor growth (PMID: 30962319).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SHR-A1307 EGFR Antibody 46 SHR-A1307 is an antibody-drug conjugate that consists of an auristatin analog linked to the anti-EGFR antibody Nimotuzumab with improved half-life, which inhibits cell growth in culture and reduces tumor growth (PMID: 30962319).

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA H1047R head and neck squamous cell carcinoma predicted - sensitive SHR-A1307 Preclinical - Cell culture Actionable In a preclinical study, head and neck squamous cell carcinoma cells harboring PIK3CA H1047R treated with SHR-A1307 demonstrated inhibition of cell growth in culture (PMID: 30962319). 30962319

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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