Profile Response Detail

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Molecular Profile APC dec exp
Therapy G007-LK
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC dec exp colorectal cancer predicted - sensitive G007-LK Preclinical Actionable In a preclinical study, G007-LK treatment altered gene expression pattern and induced growth arrest in intestinal organoids established from mouse models of colorectal cancer driven by APC knockdown, decreased proliferation and promoted differentiation in APC knockdown mouse models (PMID: 31337618). 31337618
PubMed Id Reference Title Details
(31337618) Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition. Full reference...