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Molecular Profile | PIK3CA E453Q PIK3CA H1047R |
Therapy | GDC-0077 |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E453Q PIK3CA H1047R | breast cancer | sensitive | GDC-0077 | Preclinical - Cell culture | Actionable | In a preclinical study, breast epithelial cells expressing PIK3CA E453Q and PIK3CA H1047R in cis demonstrated increased sensitivity to growth inhibition by GDC-0077 treatment compared to cells expressing individual PIK3CA mutations in culture (PMID: 31699932). | 31699932 |
PubMed Id | Reference Title | Details |
---|---|---|
(31699932) | Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. | Full reference... |