Profile Response Detail


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Molecular Profile PIK3CA E453Q PIK3CA H1047R
Therapy Everolimus
Indication/Tumor Type breast cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E453Q PIK3CA H1047R breast cancer sensitive Everolimus Preclinical - Cell culture Actionable In a preclinical study, breast epithelial cells expressing PIK3CA E453Q and PIK3CA H1047R in cis demonstrated increased sensitivity to growth inhibition by Afinitor (everolimus) treatment compared to cells expressing individual PIK3CA mutations in culture (PMID: 31699932). 31699932
PubMed Id Reference Title Details
(31699932) Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. Full reference...