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Molecular Profile | PIK3CA R88Q |
Therapy | Buparlisib + Selumetinib |
Indication/Tumor Type | high grade glioma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA R88Q | high grade glioma | sensitive | Buparlisib + Selumetinib | Preclinical - Cell culture | Actionable | In a preclinical study, the combination therapy of Buparlisib (BKM120) and Koselugo (selumetinib) led to a synergistic effect, resulting in greater growth inhibition of astrocytoma cells expressing PIK3CA R88Q than cells with wild-type PIK3CA in culture (PMID: 29975751). | 29975751 |
PubMed Id | Reference Title | Details |
---|---|---|
(29975751) | PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. | Full reference... |